The review summarises how breast tumour progression is influenced by mechanical cues in the tumour microenvironment, including mechanotransduction, cytoskeletal remodelling, and extracellular-matrix organisation.
TNNT3 (troponin T3) is introduced as a striated-muscle protein that the authors revisit in light of prior genetic analyses linking TNNT3 to triple-negative breast cancer (TNBC), including Mendelian randomisation, colocalisation, and expression-based approaches described in earlier work.
The authors separate direct TNNT3 evidence in breast cancer from indirect mechanobiology literature and from explicitly speculative models. They state that TNNT3 should be treated as a low-evidence candidate rather than an established driver, and outline experimental approaches needed to test its role in tumour systems.
For the full argument, methods, and references, see the review in Frontiers in Cell and Developmental Biology (doi:10.3389/fcell.2026.1836170).