Bond Lab Publications

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Peer-reviewed publications from the Bond Lab and collaborators. Each citation includes quick links for lookup.

Publication List

  1. Reza Ebrahimighaei, Jon G Lees, Robin A Corey, Boyi Xiao, Christopher Williams, Himali Y Godage, Vealmurugan Sekar, Hunaid Vohra, Deborah K Shoemark, Andrew C Newby, Mark Bond (2026) In silico discovery and characterisation of a novel nuclear transcription factor-Y (NF-Y) inhibitor with anti-mitogenic properties. J Med Chem. 69(7):8115-8129.
  2. Yildirim-Buharalioglu G, Sala-Newby GB, Bond M, Newby AC (2025) Epigenetic regulation of TIMP-3 expression in human macrophages via physiological and pharmacological modification of histone3 lysine27 (H3K27). Mol Biol Rep. 52:775.
  3. McNeill MC, Li Mow Chee F, Ebrahimighaei R, Sala-Newby GB, Newby AC, Hathway T, Annaiah AS, Joseph S, Carrabba M, Bond M (2024) Substrate stiffness promotes vascular smooth muscle cell calcification by reducing levels of nuclear actin monomers. J Mol Cell Cardiol. 187:65-79.
  4. Ebrahimighaei R, Tarrasova N, Bond SC, McNeill MC, Hathway T, Vohra H, Newby AC, Bond M (2023) Extracellular matrix stiffness controls cardiac fibroblast proliferation via the Nuclear Factor-Y (NF-Y) transcription factor. BBA Mol Cell Res. 1871:119640.
  5. Ebrahimighaei R, Sala-Newby GB, Hudson C, Kimura TE, Hathway T, Hawkins J, McNeill MC, Richardson R, Newby AC, Bond M (2022) Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation. BBA Mol Cell Res. 1869:119329.
  6. Corbin LJ, White SJ, Taylor AE, Williams CM, Taylor K, van den Bosch MT, Teasdale JE, Jones M, Bond M, Harper MT, Falk L, Groom A, Hazel GGJ, Paternoster L, Munafo MR, Nordestgaard BG, Tybjaerg-Hansen A, Bojesen SE, Relton C, Min JL, Smith GD, Mumford AD, Poole AW, Timpson NJ (2022) Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function. Circ Res. 130:384-400.
  7. Hawkins JW, McNeill MC, Ebrahimighaei R, Mellor HH, Newby AC, Bond M (2022) Cyclic-AMP increases nuclear actin monomer which promotes proteasomal degradation of RelA/p65 leading to anti-inflammatory effects. Cells.
  8. McNeill MC, Wray J, Sala-Newby GB, Hindmarch CT, Smith SA, Ebrahimighaei R, Newby AC, Bond M (2020) Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD. BBA Mol Cell Res. 1867:118691.
  9. Ebrahimighaei R, McNeil M, Smith SA, Wray J, Ford K, Newby AC, Bond M (2019) Elevated cyclic-AMP represses expression of EPAC1 by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. BBA Mol Cell Res. 1866:1634-1649.
  10. Smith S, Newby AC, Bond M (2019) Ending Restenosis: inhibition of vascular smooth muscle cell proliferation by cAMP. Cells. 8:1447.
  11. Smith S, Sessions RB, Shoemark D, Williams C, Ebrahimighaei R, McNeill M, Crump MP, McKay T, Harris G, Newby C, Bond M (2019) Anti-proliferative and anti-migratory effects of a novel YAP-TEAD interaction inhibitor identified using in silico molecular docking. J Med Chem. 62:1291-1305.
  12. Hudson C, Kimura TE, Duggirala A, Sala-Newby GB, Newby AC, Bond M (2018) Dual role of CREB in the regulation of VSMC proliferation: mode of activation determines pro- or anti-mitogenic function. Sci Rep. 8:4904.
  13. Greenhough A, Bagley C, Heesom KJ, Gutrvich DB, Gay D, Bond M, Collard TJ, Paraksjeva C, Martin P, Sansom OJ, Malik K, Williams AC (2018) Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 10:e8699.
  14. Smith M, Kimura TE, Hudson C, White S, Sala-Newby GB, Newby AC, Bond M (2017) Divergent regulation of actin dynamics and MKL1/2 by cAMP in endothelial cells and smooth muscle cells. Sci Rep. 7:3681.
  15. Khaliulin I, Bond M, James AF, Dyar Z, Amini R, Johnson JL, Suleiman MS (2017) Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac. Br J Pharmacol. 174:438-453.
  16. Kimura TE, Duggirala A, Smith MC, White S, Sala-Newby GB, Newby AC, Bond M (2016) The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J Mol Cell Cardiol. 90:1-10.
  17. Duggirala A, Kimura TE, Sala-Newby GB, Johnson JL, Newby AC, Bond M (2015) cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of CCN1. J Mol Cell Cardiol. 79:157-168.
  18. Kimura TE, Duggirala A, Hindmarch CCT, Hewer RC, Cui M, Newby AC, Bond M (2014) Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. J Mol Cell Cardiol. 72:9-19.
  19. Hernandez-Negrete I, Sala-Newby BG, Perl A, Kunkel GR, Newby AC, Bond M (2011) Adhesion-dependent Skp2 transcription requires STAF. Biochem J. 436:133-143.
  20. Bond M, Wu YJ (2011) Proliferation unleashed: the role of Skp2 in vascular smooth muscle cell proliferation. Front Biosci. 16:1517-1535.
  21. Hewer R, Sala-Newby G, Newby AC, Bond M (2009) Synergistic action of Epac and PKA in cAMP-induced inhibition of smooth muscle cell proliferation and stellate morphology. J Mol Cell Cardiol. 50:87-98.
  22. Wu YJ, Sala-Newby GB, Shu KT, Yeh H, Nakayama KI, Nakayama K, Newby AC, Bond M (2009) Skp2 promotes vascular smooth muscle cell proliferation and neointima formation in vivo. J Vasc Surg. 50:1135-1142.
  23. Wu J, Yehl HI, Hou CJY, Tsai CH, Newby AC, Bond M (2008) Beyond oncogenesis: the role of Skp2 in vascular restenosis. Int J Gerontol. 2:158-166.
  24. Bond M, Wu J, Sala-Newby G, Newby AC (2008) Rac1 regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo. Cardiovasc Res. 80:290-298.
  25. Muzaffar S, Shukla N, Bond M, Sala-Newby G, Angelini GD, Newby AC, Jeremy JY (2008) Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human VSMCs in response to U46619. Prostaglandins Leukot Essent Fatty Acids. 70:247-255.
  26. Muzaffar S, Shukla N, Bond M, Newby AC, Angelini GD, Sparatore A, Del Soldato P, Jeremy J (2008) Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human VSMCs. J Vasc Res. 45:521-528.
  27. Muzaffar S, Shukla N, Bond M, Sala-Newby G, Angelini GD, Newby AC, Jeremy JY (2008) Superoxide from NADPH oxidase upregulates PDE5 in human VSMCs: inhibition with iloprost and NONOate. Br J Pharmacol. 155:847-856.
  28. Wu J*, Bond M*, Sala-Newby GB, Newby AC (2006) Altered Skp2 levels are a major mediator of cyclic nucleotide-induced inhibition of VSMC proliferation. Circ Res. 98:1141-1150.
  29. Bond M, Sala-Newby G, Wu YJ, Newby AC (2006) Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI3-kinase and Skp2-mediated degradation. Cardiovasc Res. 69:198-206.
  30. Sala-Newby GB, George SJ, Bond M, Doot GK, Newby AC (2005) Regulation of vascular smooth muscle cell proliferation, migration and death by heparan sulfate 6-O-endosulfatase1. FEBS Lett. 579:6493-6498.
  31. Bond M, Sala-Newby G, Newby AC (2004) FAK-dependent regulation of Skp-2 stability: a novel mechanism regulating smooth muscle cell proliferation. J Biol Chem. 279:37304-37310.
  32. Bond M, Murphy G, Bennett M, Newby AC, Baker AH (2002) TIMP-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. J Biol Chem. 277:13787-13795.
  33. Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Walsh L, Bond M, Baker AH, Anand-Apte B (2003) TIMP-3 inhibits angiogenesis by blocking VEGF binding to VEGFR2. Nat Med. 9:407-415.
  34. Hussain S, Bond M, Assender JW, Murphy G, Newby A (2002) Activation of PKC-zeta is essential for cytokine-induced MMP-1, -3 and -9 secretion and inhibits proliferation. J Biol Chem. 277:27345-27352.
  35. Chase AJ, Bond M, Crook MF, Newby AC (2002) Role of NF-kB activation in MMP-1, -3 and -9 secretion by macrophages and foam cells. Arterioscler Thromb Vasc Biol. 22:765-771.
  36. Bond M, Chase AJ, Newby AC (2001) Inhibition of NF-kB reduces MMP-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res. 50:556-565.
  37. Bond M, Murphy G, Bennett M, Amour A, Knauper V, Newby A, Baker AH (2000) Localization of TIMP-3 death domain to N-terminus: metalloproteinase inhibition is associated with pro-apoptotic activity. J Biol Chem. 275:41358-41363.
  38. Bond M, Baker AH, Newby AC (1999) NF-kB activity is essential for MMP-1 and -3 up-regulation in rabbit dermal fibroblasts. Biochem Biophys Res Commun. 264:561-567.
  39. Bond M, Fabunmi RP, Baker AH, Newby AC (1998) Synergistic up-regulation of MMP-9 by growth factors and inflammatory cytokines requires NF-kB. FEBS Lett. 435:29-34.